Search results for " near infrared"

Near infrared light to promote synaptic resilience to Alzheimer’s Disease neuropathology

Alzheimer’s Disease (AD) is a multifactorial neurodegenerative dementia with no curative therapeutic options. One of the earliest impairments in AD triggering cognitive decline is the synaptic dysfunction induced by the selective targeting and interruption of the synaptic region by the small oligomeric form of amyloid beta (Aβ). Recently, the co-presence of Aβ oligomers (Aβo) and tau oligomers (tau-o) at the synapses has been suggested to exacerbate this dysfunction. Therefore, the development of therapeutics aimed at protecting the synapses from the toxic binding of both proteins at the synapses can preserve synaptic health and cognitive function. With this goal in mind, the present study …

Progettazione e realizzazione di un sistema Continuous Wave fNIRS basato su tecnologia SiPM

Optical techniques represent a suitable tool for in vivo and non-invasive diagnosis of human brain and tissues. Functional Near InfraRed Spectroscopy (fNIRS) is revealing as an emerging neuroimaging technology, since it is safe, relatively inexpensive and little cumbersome. fNIRS relies on the measurement of the oxygen concentration in the blood by means of light beams impinging on the tissues under test. Haemoglobin concentration variations (oxygenated/deoxygenated) can provide very important information on brain activity and allow to discriminate the main brain area involved during tests. Herein, we present the design and development of an innovative solution for a portable continuous wav…

Design of a portable (CW) fNIRS embedded system

2014

Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subse…

2018

Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown. The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective. We found that experimental ischemic stroke promoted an early extravasation of circulating iron-loaded transferrin (holotransferrin, HTf) to the ischemic brain parenchyma.…

Modulation of hippocampal neurogenesis by Nano-Pulsed Laser Therapy

Neurogenesis is a physiological process through which new neurons are generated and it occurs throughout life, subverting the old dogma stating to the inability of the adult brain to replace neurons. Specifically, neurogenesis take place thanks to the presence of neuronal stem cells (NSCs) located in the subventricular zone of the lateral ventricle and in the subgranular zone of the dentate gyrus of the hippocampus. Data present in the literature demonstrate that neurogenesis in the hippocampus decreases during aging and it is impaired in neurodegenerative diseases, such as Alzheimer’s disease, and after traumatic brain injury (TBI). Traumatic Brain Injury (TBI) is a chronic disease that oc…

Design and development of a continuous wave functional near infrared spectroscopy system

2014

Functional Near InfraRed Spectroscopy uses light sources and optical detectors for human brain monitoring. In this paper, a portable, low cost, battery-operated, multi-channel, continuous wave fNIRS embedded system, hosting up to 64 LED sources and 128 Silicon PhotoMultiplier optical detectors, is reported on. The designed system is based on a scalable architecture, in which each probe consists of 8 modular and flexible stands, able to host 4 bi-color LEDs as light sources, 16 silicon photomultipliers as photodetectors and a temperature sensor. The hardware structure allows to easily set up several relevant parameters: the timing of the LEDs, the optical power emitted by the LEDs; the acqui…

Design and realization of a portable multichannel continuous wave fNIRS

2014

A design and implementation of a portable functional Near InfraRed Spectroscopy embedded system prototype is described. In this theoretical and experimental work, we present an embedded system hosting 64 LED sources and 128 Silicon PhotoMultiplier detectors (SiPM). The elementary part of the structure is a flexible probe “leaf” consisting of 16 SiPMs, 4 couples of LEDs, each operating at two wavelengths, and a temperature sensor. The hardware system is based on an ARM main microcontroller that allows to perform both the switching time of LEDs and the acquisition of the SiPM outputs. The performed preliminary experimental tests achieved very promising results, thus demonstrating the effectiv…

Progettazione e realizzazione di un sistema Continuous Wave fNIRS basato su tecnologia SiPM

2014

Design of a Multichannel Continuous Wave fNIRS System implemented with SiPM

2013

Brain Monitoring Via an Innovative CW-FNIRS System

2015

Functional Near InfraRed Spectroscopy (fNIRS) is an imaging technique mainly devoted to human brain monitoring. It is used as a non-invasive technique, in medical field, in order to measure the oxygen concentration of blood. This because the relatively good transparency of biological materials in the near infrared allows sufficient photon transmission through tissues. Within the so-called fNIRS range (650-900 nm), the main absorbers are blood chromophores, in particular the oxygenated and deoxygenated haemoglobin (HbO2 and Hb, respectively). When two or more wavelengths are used, changes of such chromophores can be computed by employing the modified Beer-Lambert law, thus providing importan…